US shares open flat with pharmaceutical stocks down after drugs giant Eli Lilly said it would stop developing its Alzheimer drug following a trial failure.
Eil Lilly was down 14%, and rival Alzheimer drug developers Biogen and Axovant were down more than 5%.
Healthcare stocks, like other sectors, had been hitting record highs in the wake of the presidential election.
The Dow fell 4 to 19,019.49 points and the S&P 500 fell 6 to 2,196.71.
The Nasdaq lost 28 points to 5,358.12.
Reports that two patients had died in a trial of its leukaemia drug sent Juno Therapeutics down 33%.
Tractor giant John Deere though was an outstanding performer, rising 11% after its quarterly sales and earnings beat expectations.
Clothing maker Urban Outfitters dropped 8% after its sales undershot hopes.
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